Epigenetic Modifications Related to Oxidative Stress in Ischemic Stroke |Biomedgrid

Epigenetic study of heritable modifications of genome without changes in DNA sequence. Recent investigations have documented the importance of these modifications in the regulation expression of genes involved in cell cycle, proliferation and differentiation. Imbalance of epigenetic modifications leads the development of several pathologies. In this review, we describe the relationship between epigenetic modifications and oxidative stress, pointed out the putative use of these changes as potential biomarkers or as therapeutic targets in ischemic stroke.