Comparative Effect of Selected Ergot-Derived Dopamine on the Kidney Function of Wistar Rats |Biomedgrid

Ergot derived dopamine are chemical derivatives used in the treatment of certain conditions and disorders. The use of these drugs, despite its numerous heath advantages can pose a threat to the health and general metabolism when administered in unprescribed doses and time. This study evaluated the comparative effect of bromocriptine and cabergoline on the functionality and integrity of the Kidney. Twenty albino rats of wistar grain, weighing between 100-180g were used for this study. They were grouped into 5 groups with each of the group containing 5 rats. Group 1 was the control group, Group 2-5 were Low dose Bromocriptine, High dose Bromocriptine, Low dose Cabergoline, and High dose Cabergoline respectively. The drugs were administered at the various doses on a 24-hour basis. After a period of 21 days, the animals were sacrificed and blood samples were collected for bioassay on the urea, creatine and serum electrolytes as indicators of kidney function using Standard laboratory procedures, the kidney was harvested for histological examination.