The influence of benfuram on the state of lipid metabolism in rats on the background of simulated hypercholesterinemia (In Ukrainian)

The study purpose was to research the effect of course administration of benfuram on lipid metabolism during experimental hypercholesterolemia in laboratory animals. Experimental hypercholesterolemia in animals was accompanied by the reduce of the high-density lipoproteins (HDL-C) level by 22.2% with a simultaneous increase in total cholesterol (TC) of 2.11 times, increased of low-density lipoprotein (LDL-C) levels in 5.89 times and very low-density lipoproteins (LDL-VLDL) by 2.59 times, the common lipid in 1.61 times and in 2.52 times for triacylglycerols. The treatment of the experimental hypercholesterolemia by benfuram helped to raise the high-density lipoprotein (HDL-C) level by 18.1% with a simultaneous decrease of total cholesterol by 37.8% in rat plasma, decrease in the LDL-C amount by 22.8%, very low-density lipoproteins (VLDL-cholesterol) – 68.6%, triacylglycerol 59.1%, total lipids for 3.5% in comparison with EH. Benfuram is a promising substance for further search of the specific activity with the purpose to create an effective drug for the lipid metabolism regulation. Based on the results of the above study, the authors concluded that (1) against the background of experimental hypercholesterolemia under the action of benfuram and nicotinic acid in the blood serum, a shift in most indicators of lipid metabolism towards normalization was observed; (2) benfuram is a promising organic compound for further study of pharmacological properties and safety in order to create an effective drug for correcting lipid metabolism on its basis.