EXPLORING THE LANDSCAPE OF HUMAN GENE THERAPY: A CROSS-SECTIONAL STUDY AMONG MEDICAL FACULTIES IN MAHARASHTRA

Introduction: Human gene therapy holds immense potential for treating various genetic disorders and diseases by introducing therapeutic genes into patients cells. However, its successful implementation relies not only on technological advancements but also on the understanding, attitude, and awareness among medical professionals. This study aims to assess the knowledge, attitude, and awareness of human gene therapy among medical faculties of a college in Maharashtra. Methodology: A cross-sectional study was conducted among medical faculties of a college in Maharashtra. A structured questionnaire was developed, consisting of sections on demographics, knowledge, attitude, and awareness regarding human gene therapy. The questionnaire was distributed among the faculties, and data were collected anonymously. Results: Out of the total respondents (N=150), the majority were between the ages of 30-55 years (65.3%) and had teaching experience ranging from 1 to 10 years (76.7%). Regarding knowledge, only 82% of the faculties had adequate knowledge of human gene therapy, while 15.3% had moderate knowledge, and 2.7% had poor knowledge. The attitude towards gene therapy was generally positive, with 98% of respondents agreeing that gene therapy holds promise for treating genetic diseases. However, concerns were raised regarding ethical issues (62.7%) and safety concerns (55.3%). In terms of awareness, 79.3% of faculties reported receiving minimal or no information about gene therapy during their medical education. Discussion: The findings reveal excellent to fair knowledge of human gene therapy among medical faculties in Maharashtra. Despite the positive attitude and awareness towards its potential benefits, concerns regarding ethics and safety underscore the need for comprehensive education and training in this field. Integrating gene therapy-related topics into medical curricula and providing continuous professional development opportunities can help bridge this gap. Conclusion: This cross-sectional study highlights excellent knowledge about gene therapy but , there is a need for enhancing knowledge and awareness of human gene therapy among medical education in Maharashtra. Addressing this gap is crucial for preparing future healthcare professionals to effectively utilize and contribute to advancements in gene therapy research and practice. Collaborative efforts involving educational institutions, professional organizations, and policymakers are essential to ensure comprehensive training and education in this rapidly evolving field.