SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NOVEL QUINOLINE DERIVATIVES

This study presents the synthesis and antimicrobial evaluation of a series of novel quinoline derivatives. The structures of the synthesized derivatives were confirmed through spectroscopic techniques, including IR spectrometry. The antimicrobial activities of these quinoline derivatives were assessed against a panel of Gram-positive and Gram-negative bacterial strains disc diffusion method. Several compounds exhibited significant antimicrobial activity, with minimum inhibitory concentrations (MICs) comparable to standard antibiotics. The structure-activity relationship (SAR) analysis revealed that substitutions at specific positions on the quinoline ring significantly influenced the antimicrobial efficacy. These findings suggest that the synthesized quinoline derivatives hold potential as promising candidates for the development of new antimicrobial agents.