Dermatocosmetics Facial Masks for Topical Treatment of Acne

Acne is one of the most common skin diseases affecting mostly adolescents, but can occur also into adulthood. Acne can have profound psychological and social effects, not only for high severity acne, but even in less severe cases. Staphylococcus epidermidis (S. epidermidis) bacteria and Propionibacterium acnes (P. acnes) bacteria are considered to cause this disease. Over time they have used many treatments for acne especially antibiotics, metronidazole showing positive effects and long-lasting. Thus, the purpose of this study was to design and investigate some facial masks in form of membranes with collagen and metronidazole to reduce and prevent adverse effects of conventional treatments using for acne. Type I fibrillar collagen gel was the main component of all masks. Hydrogels based on collagen, metronidazole, starch and polyvinilpyrolidone showed a pseudoplastic behavior with yield stress facilitating their flow and allowing their good manipulation. The membranes were obtained by drying the hydrogels in controlled environment and characterized by water absorbtion and enzymatic degradation. The results relieves that the presence of polymers (starch and polyvinylpirolidone) influence the stability and integrity of the membranes obtain. Based on these results, we could conclude that the obtained masks are potentially usable as a favorable solution in acne disease.