The Action of Ciprofloxacin on Bacterial Infection caused by Staphylococcus epidermidis on Wounds

Staphylococcus epidermidis is a member of the skin microflora that can develop in hospitals and become a pathogen, especially in immunocompromised patients. Although it has fewer exoenzymes and virulence factors than Staphylococcus aureus, it occasionally causes infection. This study aimed to study the effect of S. epidermidis on induced hamster wound healing and compare it with ciprofloxacin antibiotics used to treat pathogen bacteria, in addition to studying physiological and some immunological parameters. S. epidermidis isolates were taken from Tikrit Teaching Hospital and identified using a VITEK 2 compact system. Hamsters were obtained and kept under typical conditions at the veterinary college and divided into third groups during each stage of the study. Briefly, the induced wounds without contaminated bacteria healed more slowly than those in the contaminated group. The therapy group achieved good outcomes, with wounds healing rapidly. Hematological data showed constant white blood cells (WBCs) in G1, whereas G2 raised WBCs, indicating the presence of pathogen bacteria. The treatment group's WBCs dropped, and red blood cell (RBC) levels remained almost unchanged. Hemoglobin levels improved to normal in the G3, and platelet levels remained stable in the treated group. C-reactive protein (CRP) levels were stable in animals with wounds but increased in contaminated wounds. Medically treated wounds had lower CRP levels. Kidney and liver health indices remained unchanged, and immunoglobulin levels remained within the normal range. The results conclude that pathogen bacteria affect the healing rate of induced wounds, which take longer to cure compared with therapy and non-therapy wounds.