Study of Bulgarian Plant Extracts Effect on Three Bacterial Sialidases

Since sialidase is a pathogenicity factor in certain microbes, it is important to inhibit it as this could have both preventative and therapeutic impacts on a number of diseases. Viral sialidase inhibitors have pre¬viously produced significant effects, but there are few experiments of the same kind on bacterial enzymes. The ability of some extracts from Bulgarian plants to inhibit the sialidases of Vibrio cholerae non-O1, Arthrobacter nicotianae, and Oerskovia paurometabola was investigated. Extracts from Rosa damascena, essential oil from Origanum vulgare ssp. hirtum and acetone exudate from Helichrysum arenarium were found to have an inhibitory effect on the studied enzymes. The influence of the extracts on bacterial siali¬dase activity was investigated for the first time. It was found that 5% Triton X-100 used for extract dilution has inhibitory effect on sialidase produced from O. paurometabola (76%), from V. cholerae non-O1 (30%) and has no effect on A. nicotinae.