Determining the Effect of Hydroalcoholic Extract of Anvilia Garcini on Ulcerative Colitis

Introduction: Ulcerative colitis is a chronic inflammatory disease of the colon and rectum, which is associated with symptoms such as rectal bleeding, diarrhea, and sometimes abdominal pain. Anvilia Garcini is a flavonoid that has anti-inflammatory and antioxidant properties. This research was designed to evaluate the effects of Anvilia Garcini for the treatment and control of inflammation in an animal model of ulcerative colitis. Materials and methods: In this experimental study, after inducing colitis with acetic acid, male rats were divided into 6 groups of 5 (negative control group, enema treatment with Asacol, oral treatment with mesalazine 10 mg.kg, oral treatment with Anvilia dose 250 and 500 ml gram, enema was divided with Anvilia 250 mg.kg). All rats were examined in terms of body weight changes, tissue changes and biochemical indicators of MPO, MDA. Results: The largest weight gain was the Asacol enema group, Anvilia enema (250 mg.kg), Mesalamine oral treatment, Anvilia oral treatment (500 mg.kg), Anvilia oral treatment (250 mg.kg) and finally the control group It was negative. The negative control group was significantly different from the treatment groups in terms of wound and inflammatory cell secretion and reduction of mucous cells. Conclusion: Treatment with Anvilia Garcini improved the reactions which were confirmed by changes in oxidative stress markers, improved disease severity index, and reduction of tissue scars. Therefore, Anvilia Garcini reduces the symptoms of ulcerative colitis. As a result, the use of Anvilia Garcini as a substance of plant origin with much less side effects can be used as a new method for the treatment of ulcerative colitis.