Monocyte Chemoattractant Protein 1’s Role in Glomerular Pathology |Biomedgrid

Chemokines represent a family of secreted proteins with an important role in the immune response, being mainly involved in cellular migration processes of leukocytes, but also of other types of cells (endothelial cells, epithelial cells). Chemokines are classified according to their primary amino acid structure and the distribution of the 4 cysteine residues into four families: CXC, CC, CX3C and XC. Chemokines interact at the level of transmembrane receptors linked to the G protein, which are found on the surface of target cells [1].