HE PHYSIOLOGICAL PARAMETERS OF RABBIT HEART WITH EXPERIMENTAL HYPERTHYROIDISM

The aim of this study was to evaluate physiological parameters of cardiac contractility in rabbit heart with hyperthiroid condition experimentally induced with T3. Our study has been done on 10 male rabbits treated with T3 (i.p. injections 4.5 mg/kg body weight) fo 4 weeks. Rabbit hearts have been mounted in a Langendorf retrograde perfusion system and after 30 minutes ischemia followed by 60 minutes reperfusion with Krebs Hanseleit bicarbonate-buffered saline at 37o C, pH 7.6 supplemented with 10 mM glucose, left ventricular developed pressure (LVDP), heart rate (H.R.) and coronary flow (C.F.) have been measured. Our data have pointed out that as far as LVDP parameter is concerned, in T3 treated rabbits, cardiac recovery is achieved at higher values above those from controls. Cardiac frequency is not different in T3 treated rabbits in comparison with controls. There is a decrease in coronary flow in hyperthyroid rabbit heart in comparison with controls, in both cases there is a decrease of this parameter during reperfusion with lower values in controls and a tendency of reaching a plateau value.