NAD (P) H: Quinone Oxidoreductase 1 Gene C609T Polymorphism and Alzheimer's disease risk

NAD (P) H: Quinone Oxidoreductase 1 (NQO1) is an enzyme that reduces cellular oxidative stress by scavenging free radicals. Variant NQO1 enzyme role in Alzheimer's disease (AD) susceptibility is controversial. The aim of the present study was to assess NQO1 C609T polymorphism as a risk factor for Alzheimer's disease (AD). The authors performed a meta-analysis from published case-control studies that examined the association between C609T polymorphism and AD (735 cases and 828 controls). The pooled Odd Ratios (OR) was estimated by both fixed effects and random effects models. The meta-analysis with random effects model showed that there was 38% heterogeneity between five included studies. The random effect pooled OR is 1.38 (95% CI; 1-14 to 1.66) and Cochran Q was 6.45 (df = 4). The results of present meta-analysis showed that NQO1 gene C609T polymorphism is a risk factor for AD pathogenesis.