The Effects of Probiotic Supplementation on Alzheimer’s Disease |Biomedgrid

Alzheimer's Disease (AD) is the leading cause of dementia and is fastly becoming one of the deadliest and most serious diseases of this century. It is a pathology that mostly affects the elderly, with still uncertain causes, largely affecting the cognition of patients. Recognition of multiple causative genes and means of protection, identification of new imaging tests with biomarkers, and screening of disease-modifying treatments is important for society. The understanding of the gut-brain axis relationship to reduce the symptoms of this disease has become more and more famous, in this perspective, the study of probiotics is of great value. The objective of this work is to review, through an analysis of clinical studies, the impact of the use of probiotics on the reduction of AD symptoms. This is an integrative literature review, with studies published in the last 5 years in English and Portuguese, with searches consulted in the specialized databases SCIELO and PUBMED, the latter including MEDLINE, with their respective descriptors in Health Sciences - DeCS: Probiotics (probiotics); Alzheimer's; symptoms (symptoms) using the Boolean operator (AND). At the end of the search, 18 articles related to the proposed theme were analyzed. It was verified that there is a symptomatic reduction of AD both in humans and in mice and rats, mainly in cognitive functions, mood, learning capacity, long and short-term memory with different probiotic classes. It is known that AD has many pathways of development, but a diet with different probiotics can significantly reduce neuroinflammation and neurodegeneration.