EFFECTS OF CIS-PLATINUM ON THE BIOCHEMICAL HOMEOSTASIS IN RATS NOTE I. INVESTIGATIONS ON THE HEPATIC DNA AND ON SERUM PROTEINS

Cytostatic chemotherapy induces changes in the homeostasis of the hepatic DNA and of serum proteins. Among the various drugs used in the chemotherapy the alkilating agents, antimetabolites, steroid hormones and antibiotics are better known. In the last decades there were discovered other new compounds such as platinum derivates which representia distinct class of compounds, having specific antitumoral action. Among platinum derivatives an essential effect has cis-platinum. Research on the cytostatic activity of cis-platinum implies the knowledge of the pharmacokinetic and biochemical effects. Experiments "in vivo" performed on Wistar strain rats pursued the action of the intraperitoneally injected cis-platinum on the hepatic deoxyribonucleic acid (DNA) biosynthesis and on serum proteins. The statistically processed analytical data revealed non-significant decreases of the hepatic DNA and of serum proteins concentrations. Electrophoretical fractions showed hypoalbuminemia and hyperglobulinemia. In case of globulin subfractions the decrease of α1 - and α2 - and increase of β - and γ - globulins was observed.