Experimental validation of the use of surgical adhesives on the stomach in rabbits

The application of supplementary hemostatic techniques for the prevention of postoperative complications is becoming increasingly widespread. In cardiovascular surgery, wound sealing using surgical adhesives has proven effective; however, this method is rarely applied in gastrointestinal procedures. The present study examined various surgical adhesives and evaluated different approaches to closing gastrotomy wounds in rabbits using latex-based tissue adhesive and gelatin-resorcinol adhesive. A comparative analysis of these adhesives was performed based on their clinical efficacy, as well as pathological and histological findings. Clinically healthy laboratory rabbits were selected as experimental subjects. Surgical interventions were performed identically across all groups, with the only difference being the type of adhesive used. Postoperative monitoring included clinical examinations, pathological assessments, histological analyses, and hematological testing. Hematological studies revealed no correlation between the type of surgical adhesive and blood parameters. The study concludes that gelatin-resorcinol surgical adhesive represents the optimal choice for additional sealing of sutures. The research was conducted at the Department of Veterinary Surgery, Moscow State Academy of Veterinary Medicine and Biotechnology named after K.I. Skryabin.