DEVELOPMENT OF NOVEL STEROIDAL AND NON-STEROIDAL ANTI-INFLAMMATORY AGENTS IN PRE-CLINICAL MODELS OF PSORIASIS

Psoriasis is a T-cell-mediated chronic inflammatory skin disease believed to be of autoimmune nature, which is characterized by circumscribed, red, thickened plaques with an overlying silver-white scale. In the present study, sensitization followed by challenge with subsequent oxazolone in acute and chronic model, observed a significant increase in ear thickness and ear weight, tissue level cytokine and circulating WBC and monocyte. In this study, we treated animal with GR agonist iso-flupredone acetate and DPC-333 either oral or systemic was found to inhibit the increase in ear thickness and weight to bring the cytokine levels down the level of prednisolone (positive control) treated animals. Also novel steroid, iso-flupredone acetate was evaluated for the first time in psoriasis pre-clinical model and demonstrated more potent effect than prednisolone. In the future complete profile might present a potential to evaluate the clinical efficacy of the steroids and provide therapeutic option in psoriasis patients.