DESIGN AND DEVELOPMENT OF DRUG-POLYMER MATRIX FILMS USING POLY-ε-CAPROLACTONE-POLY ETHYLENE GLYCOL 4000 BY FILM CASTING TECHNOLOGY

The main purpose of the study was to deliver the drug in zero order kinetics by using Drug-polymer matrix films. Film casting technique was followed to prepare Drug-polymer matrix films. All formulations were subjected to various physiochemical evaluations like Thickness, Uniformity of weight, Swelling index, Surface pH, Folding endurance, Drug content, in vitro drug release studies, Release rate kinetics were investigated. The Drug-polymer matrix films were smooth and passed all the evaluation tests performed. The in vitro kinetic treatment (Zero order and Korsemeyer’s regression value) and n values suggest that A6 was the best formulation with desired in vitro drug release for 48 hours which suffices the objective.