FORMULATION AND IN - VITRO EVALUATION OF ZOLMITRIPTAN ORO - DISPERSIBLE TABLETS

The purpose of this research was to develop Oro - dispersible tablets of Zolmitriptan. Orally disintegrating tablets offers a solution for pediatrics, geriatrics ; psychiatric or mentally ill people and those have difficulty in swallowing Tablets /capsules resulting in improved patient compliance. Zolmitriptan is a synthetic tryptamine derivative and is used for the treatm ent of migraine. The aim is to formulate orally disintegrating tablets of Zolmitriptan by using different Superdisintegrants like Crosspovidone , croscarmellose sodium and sodium starch glycolate with different concentrations of 2% , 3% 4% while microcrystal line cellulose , lactose aerosil magnesium stearate used as fillers. Tablets were prepared by direct compression method. The tablets were evaluated for hardness, thickness, friability, and weight variation and disin tegration time, drug content and %drug re lease studies were performed. Tablets containing Crosspovidone , as disintegrant with 4% showed 100% release within 15mins. Keywords: Zolmitriptan, orally disintegrating tablets, Crosspovidone .