Effect of Aqueous and Ethanolic Extracts of Nigella sativa Seeds on Milk Production in Rats
Journal: Journal of Acupuncture and Meridian Studies (Vol.6, No. 1)Publication Date: 2013-02-28
Authors : Hossein Hosseinzadeh; Mohsen Tafaghodi; Mojdeh Jalal Mosavi; Elahe Taghiabadi;
Page : 18-23
Keywords : black cumin; galactagogue; herbal; lactogenic; milk production; Nigella sativa;
Abstract
Nigella sativa L. is used as a galactagogue in traditional medicine. Hence, the effects of aqueous and ethanolic extracts of N. sativa seeds on milk production in rats were evaluated. The measurement of milk production was by measuring pup weight during suckling period. The intraperitoneal LD50 values of aqueous and ethanolic extracts of N. sativa were 4.23 and 4.9 g/kg, respectively. The aqueous (0.5 g/kg) and ethanolic extracts (1 g/kg) increased milk production significantly (p < 0.001), producing about 31.3% and 37.6% more milk than control, respectively. During the study period, the pups gained weight with the aqueous (0.5 g/kg, p < 0.01) and ethanolic extracts (1 g/kg, p < 0.05). It is concluded that aqueous and ethanolic extracts of N. sativa can stimulate milk production in rats.
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