DRUG UTILIZATION REVIEW OF ANTIMICROBIALS PROPHYLAXIS IN GASTROINTESTINAL SURGERIES ASSOCIATED WITH POST - OPERATIVE SURGICAL SITE WOUND I NFECTION

Aim The aim of the study to assess the prevalence of post - operative wound infection, prevalence of different microorganisms and its sensitivity pattern to commonly used antibiotics and its use. Methodology A total of 200 patients with gastrointestinal surgeries, such as appendicitis, ileal perforation, sigmoid volvulus, duodenal perforation and obstructed hernia were included in the study. Deep tissue culture was taken from the infected wound for microbiolog ical examination done by streak method, colony characters, and antibiotic sensitivity tests were done by ‘kirbey - bauer’ method. Results Out of the 200 patients, 22 patients had post - operative wound infections. Prevalence of wound infection was higher in Appendicitis than in other gastrointestinal surgeries. Pathogens that are prevalent in post - operative wound infection are Staphylococcus aureus(Appendicitis, Ileal Perforation, Duodenal Perforation), Klebsiella(Appendicitis and Duodenal Perforation, sigmoi d volvulus) Escherichia coli (Appendicitis) and Pseudomonas (Appendicitis). Isolated pathogens were tested for its sensitivity against commonly used antibiotics at the hospital. Conclusion Antimicrobial Amikacin was sensitive to all isolated pathogens wit h very low resistance profile compare to other commonly used antimicrobials at hospital. The major identified pathogens were staphylococcus aureus, followed by klebsiella.inspite of sterilization techniques, modern surgical equipments, prophylactic use of antibiotics, and post - operative wound infection still remains a challenge and contributes to patient’s morbidity and mortality