Ulcer-protective effect of Avicennia officinalis L., A common mangrove plant

Objective: Avicennia officinalis L. belonging to family Acanthaceae is a common mangrove plant known as Bani (Odiya) was investigated to evaluate the antiulcer activity of methanol leaf extracts (200 and 400 mg/kg b.w.) by two different models viz. Ethanol-Hydrochloric acid induced and Modified Pyloric ligation in Wistar albino rats.Method: The antiulcer potential of the extracts was compared with the standard drug Omeprazole (20 mg/kg b.w., p.o.). The percentage of ulcer inhibition and ulcer index was calculated and other biochemical parameters like free acidity, total acidity and pH were determined.Result: The methanolic extract at both the doses exhibited significant (p<0.01) antiulcer activity by inhibiting the ulcer and decreasing the ulcer score in both the ulcer models.