THE MANIFESTATIONS OF UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA ON THE PART OF THE CARDIOVASCULAR SYSTEM IN PATIENTS WITH ARTERIAL HYPERTENSION

Material and Methods. A survey of 62 patients with arterial hypertension (AH), stage I?-???, degree 1-3 (37 women, 25 men); mean age was 63,5±4,2 years. The object of the study was clinical and morphological changes, laboratory tests (blood lipids, C-reactive protein; seromucoid), and instrumental methods (ECG, echo-CG, ultrasound of lower limbs). Results and Discussion. A comparative analysis of patients with connective tissue dysplasia in 11,3% of patients revealed no signs of undifferentiated connective tissue dysplasia, and in 88,7% a number of symptoms and signs were observed. In the study of blood lipid spectrum, changes typical for atherogenesis activation were revealed, and, considering the observed activity of inflammatory markers, this process is active. Conclusions. The results suggest the presence of a widespread undifferentiated connective tissue dysplasia in patients with hypertension. Determining the severity of connective tissue dysplasia in conjunction with the overall process activity indicators (C-reactive protein, seromucoid) and blood lipid spectrum in patients with hypertension contributes to prediction of the clinical severity of the disease, the probability of defects development, arrhythmias and conduction disturbances of the heart, and can be used in planning of preventive and therapeutic measures. Keywords: hypertension, connective tissue dysplasia