SOLUBILITY ENHANCEMENT OF NEVIRAPINE BY HYDROTROPIC SOLUBILIZATION

Solubility enhancement of Nevirapine (NVP) was carried out by hydrotropic solubilization technique by using hydrotropic agent like citric acid. The Fourier transform‐IR (FTIR) studies indicated the possibility of bonding of Nevirapine with the citric acid. DSC was used to characterize the purity of nevirapine by showing melting point. Analytical method validation was carried out with 6.8 buffer. Syrup was formulated as a trial batch (50 ml). Stability testing of syrup was carried by freeze-thaw cycling testing. In present investigation solubility of Nevirapine was increased by 105.97 fold. Keyword: Nevirapine, hydrotropic solubilization, solubility enhancement, stability.