Immunomodulatory potentials of standardized dried fruit extract of Aegle marmelos in experimental system.

To evaluate the Immunomodulatory potentials of standardized dried fruit extract of Aegle marmelos in experimental system. The immunomodulatory activities of standardized dried fruit extract from Aegle marmelos, namely SDEAM I (100 mg/kg), SDEAM II (200 mg/kg) and SDEAM III (400 mg/kg), were studied in mice for immune inflammation: delayed type hypersensitivity (DTH) and humoral antibody with 7 days pretreatment (compared with Cyclophosphamide) and 15 day pretreatment. In addition to this, the efficiency was evaluated by Plaque forming colony test and the haematological test (WBC Count). Aegle marmelos extract was found to significantly increase the circulating antibody titre and antibody forming cells as compared to control and cyclophosphamide. In fact, antibody forming cells were found to be stimulated much earlier and the maximum antibody titre was obtained. However, increased titre indicated that the Aegle marmelos shows immunological activity. Administration of Aegle marmelos was found to stimulate the phagocytosis of macrophages i.e. significant increased in number of plaques formation as compared to control. On the basis of the results obtained in the various experimental studies, concluded that the standardized dried extract of Aegle marmelos has the potential to stimulate cell-mediated and humoral immunity.