Immune Cell Response to Negative Feedback Effect on HIV

Alteration in host-virus interaction dynamics during long-term infection by HIV necessitates consideration of inverse relationship between high viral load and density of CTL response leading to dysregulation of host immunity system. Mathematical modeling introducing negative feedback control mechanism helps in establishment of threshold condition for disease eradication as well as necessary conditions for existence of different equilibria depending on values of basic reproduction ratio. Moreover, IL-2 adjuvenated HAART therapy has been found to be highly cost-effective in recovery of the immunity status in the present mathematical model using negative feedback effect.