Single Nucleotide Polymorphisms Associated With Alimentary Fatty Liver Disease Are Not Genetic Risk Factors For Treatment-Associated Hepatic Steatosis In HIV Patients On HAART

Hepatic steatosis may occur with any type of HAART. Recently genome wide association studies have identified 5 single nucleotide polymorphisms (SNPs) predisposing to fatty liver disease in nutritional abnormalities. Using a non-invasive method termed “controlled attenuation parameter” we assessed liver fat in HAART-treated HIV-patients and correlated hepatic steatosis to genotype distribution of the 5 SNPs. Unlike alimentary fatty liver our data do not support a role of these SNPs for fatty liver disease on HAART.