Discovery potent of NovelNaproxenDerivatives Containing β-AlanylMoiety

The present work aims to synthesize novel naproxen derivatives containing β-alanine moiety. The synthesized compounds were characterized by elemental analysis, IR, mass NMR spectra, then docked into the active site to discover validated inhibitors of cyclooxygenases (COX-2). The calculations in-silico were predicted that, the compound interacted with residues of active site, may be making them possible selective inhibitors against (COX-2) and physiologically active.