The Relationship between the Degree of Obesity, Metabolic Disorders of Uric Acid and Lipid Metabolism in Patients with Hypertension and Gout

The objective of the research: to study the parameters of lipid and purine metabolism in patients with hypertension of II degree concomitant with gout, depending on the degree of obesity. Materials and methods of the research: we examined 60 patients, 42 of them with the diagnosis of essential AH of the second degree with concomitant obesity and gout and 18 with the diagnosis of essential AH of the second degree without obesity and gout. The average age of them was 60.2 ± 1.3 years. All patients were randomly divided into 4 groups. First group included 18 patients with the diagnosis of essential AH of the second degree without obesity and gout. The second group included 20 patients with the diagnosis of essential AH of the second degree with concomitant obesity of the I degree and gout. Third group included 12 patients with the diagnosis of essential AH of the second degree with concomitant obesity of the II degree and gout. The fourth group included 10 patients with the diagnosis of essential AH of the second degree with concomitant obesity of the III degree and gout. The study included calculation of body mass index (BMI). Biochemical studies included the determination of total cholesterol (TC), triglycerides (TG), high density lipoproteins (HDL), low density lipoproteins (LDL) and uric acid. Results: the dyslipidemia was found in the majority of the patients with the diagnosis of essential AH of the second degree with concomitant obesity and gout (83% - by the indexes of TG and 77% - by the indexes of HDL). ). It was proved that the level of TC increases with increasing degree of obesity. The level of TG exceeded the norm in all patients with hypertension, obesity and gout. ). In patients of the IV group the HDL level was lower by 28.6% (p < 0.05) compared to the group I, in the second and third group, respectively, by 25.4% and 22.2% (p < 0.05). The level of uric acid in patients with obesity and gout (II, III and IV group) exceeded the norm, and was significantly higher compared to the group I of patients. The presence of direct correlation between the total hypercholesterolemia, total hypertriglyceridemia, LDL, uric acid, and regressive correlation between HDL and the level of BMI was proved. Conclusions: individuals with a higher degree of obesity are more prone to the development of dyslipidemia. Taking into account the obtained results, more studies of the role of lipid and purine metabolism in the pathogenesis of comorbid states should be done.