Effect of Different Chemotherapy Regimens on the Development of Drug-Induced Liver Disease in Patients with Chronic Lymphocytic Leukemia

The objective of the research was to establish the frequency and variability of drug-induced liver disease (DILD) in patients with chronic lymphocytic leukemia (CLL) according to the chemotherapy (CT) regimens. It was proved an adverse effect of investigated chemotherapeutic agents on the dynamics of functional state of the liver and heterogeneity of peculiarities of drug-induced lesions of hepatocytes based on the type of drug applied due to cytostatic treatment was established. Type of drug-induced liver disease (DILD) was determined depending on the degree of increase of alanine aminotransferase and alkaline phosphatase. It was established that usage of leukeran as the main drug in the chemotherapy of chronic lymphocytic leukemia led to holestastatic syndrome (70.27%) that caused growth of serum bilirubin and alkaline phosphatase. The application of the FC scheme for the CLL treatment led to formation of the cytolysis syndrome (81.58%) with increased plasma concentration of transaminases. The use of the CHOP contributed to such signs as cholestatic cytolytic syndromes (65%). It was established the dependence of the degree of hepatotoxicity on chemotherapy regime and presence of risk factors. The presence of two or more risk factors had unfavorable prognosis regarding the degree of hepatotoxicity.?