Effect of Precursors of Nitric Oxide Synthesis on Indicators of Healthy Animal’s Bile Excretion

Nitric oxide (NO) is a biologically active substance that affects not only the vasodilation processes, but also participates in the modulation of a number of processes in the body, including the liver. However, its role in bile secretion remains unclarified. In the research we studied the effect of NO synthesis modulators on parameters of biliary function and bile synthesis of liver in healthy rats. We determined the intensity of bile secretion, content and the concentration of its major components, namely bilirubin and its fractions, cholesterol and bile acids, the ratio bile acids/cholesterol. The precursors of NO synthesis, namely L-arginine and L-glutamate L-arginine (“Glutargine” drug of pharmaceutical company “Zdorovia”) were found to cause choleretic effect. A tendency to increase in both bilirubin and bile acids was observed, mainly due to the conjugated forms of the enzyme. The ratio between the bile components was unchanged, indicating to preservation of bile lithogenic properties.