Peculiarities of Morphological Changes of Skeletal Muscles of Rats’ Lower Extremities in Cases of the Experimental Hyperuricemia

The research of the peculiarities of skeletal muscles of the prereproductive and reproductive age rats found that muscle fibers remodeling was unidirectional and manifested in swelling and sarcoplasm homogenization as well as contracture changes. However, the degree of their severity depended on animals’ age. The most significant changes presented mainly in the arteries of the femoropopliteal segments under the conditions of experimental hyperuricemia were determined. Rats of the prereproductive age were characterized by the hypertrophic type of the vascular remodeling, the animals of the reproductive age ? by the inflammatory and sclerotic types of vascular remodeling.