EFFECT OF METABOLIC PARAMETERS AND HS - CRP LEVELS ON CARDIAC AUTONOMIC FUNCTION IN PATIENTS WITH METABOLIC SYNDROME

AIM : The aim of the study was to evaluate cardiovascular autonomic function (CAF) in metabolic syndrome (MetS) patients and its association with hs - CRP and other metabolic paramet ers . Methods : A total of 125 subjects of both sexes (control: 50; MetS: 75) were included for study. From anthropometric data body mass index (BMI) and waist circumference (WC) were measured. Blood pressure (BP) and biochemical analysis of blood glucose le vels, lipid profiles and hs - CRP were done. Insulin resistance (IR) was calculated by HOMA - IR. To evaluate cardiac autonomic function we performed cold pressure test, heart rate response to standing and hand grip test were under sympathetic function, and de ep breathing test, heart rate response to valsalva were performed under parasympathetic functions. Results : The levels of hs - CRP were found to be elevated in obese with MetS subjects where it correlated significantly with its components including measures of Sympathetic and parasympathetic activity when compared to control groups. Positive correlation of hs - CRP was noted with obese MetS, SB/DP, TCHOL, TGL, VLDL, LDL, FBS, PPBS, INSULIN, HOMA IR, and Heart rate response to standing. Conclusion : Obesity with MetS seem to be associated with elevated hs - CRP and CAF determination and probably increase cardiovascular risk in obese subjects