Synthesis and anticonvulsant evaluation of benzothiazole derivatives

A series of substituted N-benzothiazole derivatives and substituted N-benzthiazole-2-yl-hydrazides were synthesized and their anticonvulsant activity was evaluated after oral administration in the MES model. The synthesized derivatives showed moderate to minor protection in anticonvulsant screening. Among the synthesized derivatives only BZT-4, BZT-5, BZT-11 and BZT-12 showed moderate activity in MES test. None of the compounds showed neurotoxicity at the maximum administered dose.