Endothelin-1 in Periodontal Diseases: A Mini-Review
Journal: Journal of Pharmacy Research (Vol.9, No. 1)Publication Date: 2015-01-11
Authors : Waleed Khalid; Sheeja S.Varghese; Reema Lakshmanan; Sankari M.; Dr.N.D. Jayakumar;
Page : 31-34
Keywords : Endothelins; endothelin-1; cytokines; chronic periodontitis; gingival overgrowth;
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Abstract
Endothlin-1 (ET-1) is a 21 amino acid peptide and is a potent vasoconstrictor produced by endothelial cells. It plays a role in the development of diseases such as hypertension and atherosclerosis. Reports have suggested the identification of ET-1 in chronic periodontitis and gingival overgrowth. Thus, there is a need to appraise the role of ET-1 in periodontal disease. Further research is needed to confirm its use as a biomarker and to incorporate endothelin-antagonists in periodontal therapy.
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Last modified: 2015-12-11 00:59:35