Formulation and Evaluation of Fast Dissolving Tablets of Ranitidine Hydrochloride

Aim: The present work fast dissolving tablets of Ranitidine Hydrochloride were designed with a view to provide quick onset of action. Ranitidine Hydrochloride which is a histamine H2-receptor antagonist belongs to class?III of Biopharmaceutical classification system. Methods: Fast dissolving tablets were prepared by direct compression method by using various super disintegrants like kollidon, croscarmellose sodium, kyron and sodium starch glycolate. Results: The powder blend was evaluated for pre-compression parameters in order to assess the flow properties of powder like bulk density, tapped density, compressibility index, hausner’s ratio, angle of repose. The powder blend showed excellent flow properties. The prepared tablets were evaluated for thickness, hardness, friability, disintegration time and in vitro dissolution studies for a period of 1 hour. Conclusion: Among all prepared tablets the (F -5) formulation containing kollidon 12.5 % w/w were emerged as the best formulation and the in vitro drug release was found to be within 30 min compared to all superdisintegrants.