Antidiabetic activity of ethanolic leaf extract of Bridelia scandens in streptozotocin induced diabetic rats

The aim of present study to evaluate antidiabetic activity of ethanolic extract of Bridelia scandens (Roxb) Wild. (Family: Euphorbiaceae) leaf in streptozotocin induced diabetic rats. The alcoholic extract of Bridelia scandens (Roxb) Wild was studied for antidiabetic activity in streptozotocin induced diabetic rats by oral administration of extract 200&400mg/kg body weight for the period of 28 days. The preliminary phytochemical study showed the presence of flavonoids, carbohydrates and glycosides, phenolic compounds and tannins. From the toxicity study it was observed that ethanolic extract of Bridelia scandens (Roxb) Wild was nontoxic up to the dose of 2000mg/kg body weight. The determination of blood glucose level by GOD-POD kit method. The effect was compared with oral dose of 0.6mg/kg Glibenclamide. The result shows the alcoholic extract of Bridelia scandens (Roxb) Wild level significantly lowered the blood glucose of hyperglycemic rats in the dose dependent manner and it was also comparable to that of the standard drug glibenclamide.