PHYTOPREVENTIVE ANTIHYPERLIPIDEMIC ACTIVITY OF CURCUMA ZEDOARIA

Curcuma zedoaria belongs to the family Zingeberaceae. Hydroethanolic extract of Curcuma zedoaria rhizome showed only the presence of alkaloids. Total phenol content was found to be 34.45±1.9 expressed as mg/g equivalent of gallic acid. Total flavonol content was found to be 45.56±2.38 mg/g equivalent of quercetin. In vitro antioxidant activity IC50 value for hydroethanolic extract was found to be 930±16.35 for DPPH method, >1000 ?g/ml for Nitric oxide method. Concentration required for reducing power was found to be 2.525±0.023 ?g/ml. total antioxidant capacity was found to be 230.2±1.32 which was expressed as mM equivalent of Ascorbic acid. The extract was found to be effective in reducing TC levels after 12 days of pre treatment with extract at a dose of 200 and 400 mg/kg b/w reduced by 17.1% and 19.65%. No significant changes were seen on LDL, VLDL and HDL cholesterol levels.