INTRAVASCULAR HOMEOSTASIS STATE IN CASE OF EXPERIMENTAL VENOUS THROMBOSIS

The most significant 76,8% decrease in the erythrocytes deformity was established to occur in the first day after venous thrombosis simulation. In the fifth day, the erythrocytes deformity was 36,7% lower than in the control group, but 29, 3% higher than in the first day after thrombin introduction. In the fifteenth day the erythrocytes deformity decreased by 16,7% in comparison with the indexes in the control group. In the first day of the experimental venous thrombosis, an increase by 40, 7% in the circulating endotheliocytes number was marked in comparison with the control. In the fifth day there was an increase of the circulating endotheliocytes number in comparison with the control indexes, but the number was 15,2% lower than in the first day. In the fifteenth day the circulating endotheliocytes number became the same as in the control group. The content of nitrates/nitrites after thrombin introduction decreased by 8,9%, and in the fifth day it wasn’t statistically different from the indexes in the control group. In the fifteenth day the nitrates/nitrites content appeared to be 16,7% higher than in the control group. Dienal conjugates (DC) concentration in the first and fifth days of the venous thrombosis simulation has 2,4 and 2,8 times increased. In the fifteenth day after thrombin introduction DC was 77,5% higher in comparison with the indexes in the control group. Consequently, acute venous thrombosis is accompanied by the erythrocytes deformity decrease, nitrates/nitrites presence in the plasma and by an increase of the circulating endotheliocytes number and DC concentration. Thus, rationality of the erythrocytes deformity, circulating endotheliocytes and dienal conjugates application is grounded in the complex examination in case of acute deep veins thrombosis.