FORMULATION AND EVALUATION OF BUCCAL PATCH OF ATENOLOL

The buccal patches of atenolol is design with hydrophilic polymers like Sodium alginate, Hydroxy propyl methyl cellulose, Carbopol 934P, PVP K-30, in their initial proportions and glycerin is used as plasticizer combinations were fabricated by solvent casting technique. The thebuccal patches are subject of great interest during recent years because it provides the possibility of avoiding the G.I.T. Contents. About 40% of drugs are lipophilic and failed to reach market due to their poor water solubility. The Buccal region is rich in blood supply, so the drugs administered in buccal region the patches are design and developed. The buccal mucosa is doing both systemic and local action. The buccal patches are preferred because they enter directly in systemic circulation and avoid hepatic first pass metabolism, due to this bioavailability of drugs are improved. Keywords: Atenolol, Buccalpatches, Hydrophilic polymers, Solvent casting method.