COGNITIVE ENHANCING ACTIVITY OF DOCOSAHEXAENOIC ACID AND GAMMA-LINOLENIC ACID IN LEAD INDUCED AMNESIA

The purpose of this study was to characterize the putative cognitive enhancing activity of docosahexaenoic acid and gamma-linolenic acid in lead induced amnesia. PRO-PL dietary supplement containing docosahexaenoic acid and gamma-linolenic acid was administered to study cognitive enhancing activity using elevated-plus maze model and employing piracetam (200 mg/kg i.p.) as the standard drug. In the elevated?plus maze, there was significant increase in time spent and number of entries into the open arms at doses of 100 and 200 mg/kg. Dietary supplement containing docosahexaenoic acid and gamma-linolenic acid showed prominent cognitive enhancing activity in mice.