DESIGN AND INVITRO EVALUATION OF METFORMIN FLOATING TABLETS USING HYDROPHILIC POLYMERS

Metformin HCl is an oral anti-diabetic drug from the biguanide class. It is the first line drug of choice and is used for the treatment of type 2 diabetes, particularly in overweight and obese people and those with normal kidney function and also as monotherapy as an adjunct to diet and exercise for the management of type 2 (non-insulin dependent) diabetes mellitus in patients whose hyperglycemia cannot be controlled by diet alone. Sustained release gastroretentive dosage forms enable prolonged and continuous input of the drug to the upper parts of gastrointestinal tract and improve the bioavailability of medication that is characterized by narrow absorption window.Gastroretentive floating drug delivery systems (GFDDS) of metformin hydrochloride, an antidiabetic drug with an oral bioavailability of only 50%(because of its poor absorption from lower gastrointestinal tract) have been designed and evaluated