VITAMIN D-BINDING PROTEIN AS MARKER OF KIDNEY TUBULOINTERSTITIAL DAMAGE IN CHILDREN WITH DIABETES MELLITUS TYPE 1

42 patients aged 6 to 17 years old suffering from type 1 diabetes (T1D) were examined. Urine levels of vitamin D-binding protein (VDBP), L-Alanine aminopeptidase (L-AP) and β-2 microglobulin (β2-MG) were determined. Urine VDBP, L-AP and β2-MG levels were elevated in the patients with T1D, compared with controls (p<0.001). Determination of urinary excretion of VDBP can be used as a marker of kidney tubulointerstitial damage in children with T1D.