EFFECTIVENESS AND IMPACT ON TOTAL BLOOD PROTEINS OF DIFFERENT METHODS OF PLASMAPHERESIS IN COMPLEX TREATMENT OF ACUTE PANCREATITIS NON-BILIARY MODERATE IN EARLY PHASE OF DISEASE

The aim ? To determine the effectiveness and impact on the level of total blood protein different methods of plasmapheresis in the complex treatment of acute pancreatitis non-biliary moderate severity in the early phase of the disease. Materials and methods. Result of treatment 103 patients: 40 (38.8%) women and 63 (61.2%) men aged 31y.o. to 73 years, on average 52,34 ± 0,94 years with severe acute pancreatitis classification of Atlanta 2012 were analysed. This patient were hospitalized at Kyiv Alexandrovskiy clinical hospital and Kyiv clinical hospital №9 in 2007-2012 incl. They were divided into two groups: a comparison (group C ? 48 patients) and basic (group B ? 55 patients). In Group C ? plasmapheresis (PF) was performed by the conventional method, in the group B ? on our proposed modification. The results are evaluated by PF changes leukocyte intoxication index (LII) and total protein level (TP). Results. In all groups achieved statistically identical decline LII first to seventh day 34,86 ± 1,27% in group C and 37,45 ± 1,4% in the group B. In the course of the study there were no significant differences between groups for mean values LII in the same time. The proposed method was also more economical, as loss of serum total protein. Patients B did not need replacement therapy (mandatory for patients with Group C, which is 9 ? 18.8% cases cause allergic reactions and the need for additional therapy). Conclusions. The proposed method PF, which differs from the traditional use of application to the processing of 55% of BCC in patients with severity AP maintains detoxification efficiency similar to traditional methods and It minimizes of “undesirable” effects. The proposed methodology provides a significant reduction in PF LII from the first to the seventh day similar to the conventional respectively 37,45 ± 1,4% and 34,86 ± 1,27% and is associated with less loss of total blood protein.