PHENYLALANINE METABOLITES AND FREE AMINO ACID POOL PARAMETERS IN URINE OF BREAST CANCER PATIENTS

Objective of study: search of diagnostically significant biochemical parameters in breast cancer patients among the levels of amino acids and phenylalanine metabolites. Methods: GC/HPLC. Results: urine level of phenylacetylglutamine in patients with breast cancer of I and II stages was found to be significantly higher than in healthy subjects. Changes in the levels of aromatic amino acids as well as in glutamine level were of less magnitude. Operative treatment (10 days after operation) did not lead to significant alleviation of the changes found.