DEFICIENCY OF VITAMIN D IN HIV INFECTED PATIENTS AND ITS EFFECT ON SOME OF THE BIOCHEMICAL PARAMETERS

Today the HIV infection is a chronic disease with significantly longer duration of the life of the patients. Different factors which could affect the progress of the HIV infection and some comorbidities are being researched. Vitamin D ( 25 ( OH ) D ) is one of those factors , which interacts with a corresponding receptor (VDR), which is expressed by a large number of organs including brain, muscle, pancreas, colon, mammar y glands and immune cells. The activation of those receptors is responsible for the so called ? nonclassical “ effects of Vitamin D. The aim of our study was to assess 25 - hydroxyvitamin D (vitamin D) status in an HIV - infected adult population , to define fac tors associated with vitamin D deficiency and to assess some ? nonclassical “ effects of Vitamin D ( association between 25 - hydroxyvitamin D (vitamin D) status and some major biochemical parameters ) . The study includes 145 HIV ? positive patients on treatment who are being monitor ed in the Department for acquired immune deficiency at Specialized Hospital for Infectious and Parasitic Diseases “ Proff. Iv . Kirov” - Sofia . The results show that most of the tested patients are with deficiency or insufficiency of 25 (OH )D. In our survey we didn’t found a statistically significant link between the 25(OH)D serum levels and the season - factor. We also didn’t found significant differences between the 25 (OH)D serum levels according to gender and age of the tested HIV - positive patients. We found reliable dependence according to the performed treatment with the Efavirenz medicament only for women. In patients with 25 (OH)D deficiency we found significant reverse correlations between the 25 (OH)D serum levels and blood sugar values and the ALT . The decrease of the 25 (OH)D serum level correlated with the increase of the blood glucose and ALT. Positive correlation between the 25 (OH)D serum levels and the creatinine, we found only in the patients with normal 25 (OH)D serum levels