Assessment of Clinical Course Intensity of Premenstrual Syndrome

Premenstrual Syndrome (PMS) is one of the most common neuroendocrine disorders in gynecology. Diagnosis of this disease, which can completely cover the total clinical picture remains to be discussed. The objective of the research was to study the intensity of clinical manifestations in women with PMS. Material and methods. The research included 200 women of reproductive age with diagnosis of PMS. Moos Menstrual Distress Questionnaire was used for diagnosis of this pathology. Control group consisted of 50 women without diagnosis of PMS. Results of the study. We found differences in the spread and severity of symptoms of diseases between women with different clinical forms. The item “sensation of pain ” was found to be the highest in patients with cephalgic and crisis forms and exceeded the indicator of healthy individuals, respectively, in 4.05 (p< 0.001) and 4.09 times (p< 0.001). The item “impaired concentration” was in 2.94 times (p< 0.001) higher in women with neuropsychical form compared with that of healthy women. The most severe “behavioral change” was determined in patients with cephalgic and crisis forms of PMS whose indices were in 3.31 times (p< 0.001) higher about the control. Item “ vegetative reaction” in women with crisis and cephalgic forms was higher than in healthy women, respectively, in 4.27 (p< 0.001) and 3.42 times (p< 0.001). The most intense “fluid retention” was observed in patients with edematous form. The index of item “negative affect” was particularly severe in women with neuropsychical form, “activity disorder” in patients with crisis and cephalgic forms of PMS. Item “control” was typical only for women with crisis form, which increased in 4.84 times (p< 0.001) compared with healthy ones. Conclusions. Moos Menstrual Distress Questionnaire is the diagnostic method that allows to estimate not only the presence but also the intensity of the specific symptoms of PMS.