The research of endothelio- and cardioprotective effects of basic antihypertensive medicines groups in combination with l- arginine in experimental endothelial dysfunction

In laboratory animals in nitric oxide deficiency modelling introduction of NO-syntase inhibitor L-NAME functional and biochemical markers endothelial dysfunctions - factor endothelial dysfunctions, myocardial loading tests (adrenoreactivity, loading by resistance), the nitrite ions content in blood whey, expression endothelial NO-syntase investigated. Endothelio- and cardioprotective effects activization of enalapril, lozartan, amlodipine, indapamide and nebivolol is revealed in their introduction in combination with L-arginine.