The influence of micelle forming process in nonionic surface active substances on diclofenak-sodium release rate from ointments

The influence of the nonionic surface active substances (long-chain fatty alcohols) on the medicinal substances release rate has been studied on the pattern diclofenak-sodium ointments (1%). The increase of the surfactant quantity in the ointment has not been found to lead a direct increase of the diclofenak-sodium release rate. Two surfactant concentrations have been determined provoking the maximum diclofenak-sodium release rate they from the ointment. Liquid crystalline phase has been shown to form when surfactant concentration exceeded the second critical micelleformation concentration, diffusion through the phase being the lowest one.