CARDIOPROTECTIVE EFFECTS OF RESVERATROL IN ISCHEMIC AND REPERFUSION MYOCARDIAL INJURYJournal: I.P. Pavlov Russian Medical Biological Herald (Vol.23, No. 4)
Publication Date: 2015-12-20
Authors : Danilenko L.M.; Pokrovsky M.V.;
Page : 30-34
Keywords : ;
The article presents the results of studies of the effect of distant preconditioning by creating short-term limb ischemia and pharmacologic preconditioning of resveratrol on the size of myocardial necrosis and the level of troponin I in serum after ischemia-reperfusion. Established a comparable protective effect as distant and pharmacological preconditioning. Possible mechanisms of the protective effect of pharmacological preconditioning during ischemia/reperfusion. Preconditioning of the heart by resveratrol provides cardioprotection, as evidenced by the reduction in the size of the area of myocardial necrosis. Cardioprotection resveratrol was completely abolished as N-nitro-L-arginine methyl ester (L-NAME), and aminoguanidine (AG), which show that resveratrol provides cardioprotection type of ischemic preconditioning by nitric oxide synthase (NOS).
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