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CARDIOPROTECTIVE EFFECTS OF RESVERATROL IN ISCHEMIC AND REPERFUSION MYOCARDIAL INJURY

Journal: I.P. Pavlov Russian Medical Biological Herald (Vol.23, No. 4)

Publication Date:

Authors : ; ;

Page : 30-34

Keywords : ;

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Abstract

The article presents the results of studies of the effect of distant preconditioning by creating short-term limb ischemia and pharmacologic preconditioning of resveratrol on the size of myocardial necrosis and the level of troponin I in serum after ischemia-reperfusion. Established a comparable protective effect as distant and pharmacological preconditioning. Possible mechanisms of the protective effect of pharmacological preconditioning during ischemia/reperfusion. Preconditioning of the heart by resveratrol provides cardioprotection, as evidenced by the reduction in the size of the area of myocardial necrosis. Cardioprotection resveratrol was completely abolished as N-nitro-L-arginine methyl ester (L-NAME), and aminoguanidine (AG), which show that resveratrol provides cardioprotection type of ischemic preconditioning by nitric oxide synthase (NOS).

Last modified: 2016-03-25 05:09:55