METABOLIC ASPECTS OF PHARMACOLOGICAL DEPRIVATION PERIPHERAL NICOTINIC SENSITIVE CHOLINERGIC SYNAPSES

Content of ATP, ADP, of AMP and activity of isozyme systems LDH in the cranial cervical sympathetic ganglia (CSSG) rabbits was investigated with partial and complete deprivation of N-cholinergic (N-HE) synapses. Dynamics of activity of LDH and content of macroergs in deprivation N-HE synapses indicates that blockade of N-HE synapses results in sympathetic ganglia to significant energy shortages and disruption of energy homeostasis. It is assumed that changes in energy metabolism are the main cause CSSG hypofunction observed during pharmacological blockade by antagonists N-HE synapses.